Wiskott-Aldrich syndrome

What is Wiskott-Aldrich syndrome? Wiskott-Aldrich syndrome is a disease of the immune system. It’s genetically inherited in an X-linked recessive manner, so it mostly affects males. The classic triad of findings include microthrombocytopenia, repeated infections, and eczema. It’s caused by a mutation of Wiskott-Aldrich syndrome protein, which is produced by all of the hematopoietic cells. Treatment is focused on controlling the symptoms and hematopoietic stem cell transplantation is currently the only potentially curative treatment.

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