Pharmacology – ANTICOAGULANTS & ANTIPLATELET DRUGS (MADE EASY)

Topics covered include: basic pathophysiology of blood clot formation, platelet function; activation, aggregation, cross-linking, ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, plasminogen. Mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.

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