Methotrexate – Pharmacology (DMARD, mechanism of action, side effects)

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“Methotrexate is a first line treatment for RA and other autoimmune diseases. It is an immunosuppressant meaning it suppresses the immune system. Methotrexate is a folic analog and works by inhibiting dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in the synthesis of nucleotides.”

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