Conn’s syndrome also known as primary hyperaldosteronism, is a tumor of adrenal glad which causes excess production of a hormone called aldosterone. The major function of aldosterone is to reabsorb sodium and excrete potassium and hydrogen ions (H+). Conn’s syndrome can be either a unilateral tumor (located on only one adrenal glad) which are also the most common adrenal tumors or bilateral tumor (located on both adrenal glands). The reason Conn’s syndrome is important is because of the fact that it is potentially curable cause of hypertension (high blood pressure).
Yes, other than Conn’s syndrome which is a primary cause of hyperaldosteronism we also have secondary causes of hyperaldosteronism which present very similar to Conn’s syndrome “primary hyperaldosteronism”.
The secondary causes of hyperaldosteronism are not due to tumors but rather, due to other manifestations that reduces the amount of blood that reaches the kidneys. Our kidney is a one of the main organs of our body which also has a huge part in maintaining the blood pressure. Kidneys maintain blood pressure through Juxtaglomerular apparatus (JGA) which includes:
Juxtaglomerular cells secrete renin in response to decrease renal blood pressure, therefor activating the Renin Angiotensin Aldosterone System (RAAS) by secreting Renin. It is important to know that Renin also increases the sympathetic tone (β1) activity of the heart leading to increase cardiac output.
The laboratory values for both Conn’s syndrome (primary hyperaldosteronism) and secondary hyperaldosteronism are exactly the same,
This video tutorial is brought to you by: Ali Feili, M.B.A., M.D.
More info on Conn’s syndrome vs Secondary Hyperaldosteronism: http://www.medical-institution.com/conns-syndrome/
This information is intended for educational purposes only, and should not be interpreted as medical advice. Please consult your physician for advice about changes that may affect your health.
This video lecture talks about Conn’s syndrome vs secondary hyperaldosteronism. It explains what Conn’s syndrome is and it differentiates it with other causes of hyperaldosteronism which are known as secondary hyperaldosteronism.