Minimal change disease

What is minimal-change disease? Minimal-change disease is a type of nephrotic syndrome characterized by cytokine damage to the glomeruli, causing effacement of the foot processes of the podocytes.

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This video covers the pathophysiology, possible causes, diagnosis, and treatment of minimal-change disease.

Effacement of foot processes – https://goo.gl/McpXML

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Sources:
Pathoma (text)
Robbins Basic Pathology (text)
First Aid USMLE Step 1 (text)
http://emedicine.medscape.com/article/243348-overview#a5
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163769/
https://en.wikipedia.org/wiki/Minimal_change_disease#Names
https://en.wikipedia.org/wiki/Nephrotic_syndrome

Credits:
Script/audio/visuals: Tanner Marshall, MS
Reviewer: Rishi Desai, MD, MPH

Attributions:
Water drop low sound effect by Mike Koenig – http://soundbible.com/1139-Water-Drop-Low.html

 

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