What is IgA nephropathy? IgA nephropathy, sometimes called Berger disease, is a type of nephritic syndrome where abnormal IgA antibody is formed, which results in immune complex deposition in the glomerular mesangium, leading to kidney disease. This video covers the pathophysiology, signs and symptoms, and treatment of IgA nephropathy.
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Pathophysiology, the biological basis for disease in adults and children, 7th Ed.
Pathophysiology )Copstead), 5th Ed.
This video was created in collaboration between Osmosis and Rush Medical College
Script/audio/visuals: Tanner Marshall, MS
Reviewer: Rishi Desai, MD, MPH
Immunofluorescence by Havill et al. – https://openi.nlm.nih.gov/detailedresult.php?img=PMC4421729_ndtplussfr054f03_3c&query=Iga+nephropathy&it=xg&req=4&npos=48
Electron microscopy by Dae-Kyoon Yim, et al. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644770/
Light microscopy by Ghani et al. – https://openi.nlm.nih.gov/detailedresult.php?img=PMC3102474_ASM-31-152-g003&query=iga+nephropathy&it=xg&req=4&npos=11
Water drop low sound effect by Mike Koenig – http://soundbible.com/1139-Water-Drop-Low.html
Rush Medical College
Maureen H. Richards, PhD