IgA nephropathy (Berger disease) – causes, symptoms, diagnosis, treatment, pathology

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What is IgA nephropathy? IgA nephropathy, sometimes called Berger disease, is a type of nephritic syndrome where abnormal IgA antibody is formed, which results in immune complex deposition in the glomerular mesangium, leading to kidney disease. This video covers the pathophysiology, signs and symptoms, and treatment of IgA nephropathy.

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Sources:
Pathoma
Pathophysiology, the biological basis for disease in adults and children, 7th Ed.
Pathophysiology )Copstead), 5th Ed.
http://jasn.asnjournals.org/content/10/8/1763/F1.expansion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541534/
http://www.nature.com/mi/journal/v1/n1/full/mi20076a.html
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2778786_467_2009_1230_Fig1_HTML&req=4
http://emedicine.medscape.com/article/239927-overview?pa=LxRPWrhyUc63T8qN3yUpr4FjmlwRcZdRM%2BHdkGM1L%2BWd6A6zyVmIDXLqSXoYDW8hETm647J2UJt5uItQ8SEPbpcPToI7ZYMaHmyzz0K1oc4%3D#a5
http://emedicine.medscape.com/article/239927-treatment
https://www.niddk.nih.gov/health-information/health-topics/kidney-disease/iga-nephropathy/Pages/facts.aspx#10
https://www.researchgate.net/publication/6309540_Underglycosylation_of_IgA_in_IgA_nephrop
athy_More_than_a_diagnostic_marker
https://en.wikipedia.org/wiki/Henoch%E2%80%93Sch%C3%B6nlein_purpura
https://en.wikipedia.org/wiki/IgA_nephropathy

This video was created in collaboration between Osmosis and Rush Medical College

Credits:
Script/audio/visuals: Tanner Marshall, MS
Reviewer: Rishi Desai, MD, MPH

Attributions:
Immunofluorescence by Havill et al. – https://openi.nlm.nih.gov/detailedresult.php?img=PMC4421729_ndtplussfr054f03_3c&query=Iga+nephropathy&it=xg&req=4&npos=48
Electron microscopy by Dae-Kyoon Yim, et al. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644770/
Light microscopy by Ghani et al. – https://openi.nlm.nih.gov/detailedresult.php?img=PMC3102474_ASM-31-152-g003&query=iga+nephropathy&it=xg&req=4&npos=11
Water drop low sound effect by Mike Koenig – http://soundbible.com/1139-Water-Drop-Low.html

Special thanks:
Rush Medical College
Maureen H. Richards, PhD

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