Alzheimer’s disease – plaques, tangles, causes, symptoms & pathology

What is Alzheimer’s disease? Alzeimer’s (Alzheimer) disease is a neurodegenerative disease that leads to symptoms of dementia. Progression of Alzheimer’s disease is thought to involve an accumulation of beta-amyloid plaque and neurofibrillary tangles in the brain. Subscribe – https://goo.gl/w5aaaV. More videos – https://goo.gl/UhOKiM. Support us on Patreon – https://goo.gl/ZGHEk4.

This video covers the mechanisms and pathophysiology thought to contribute to Alzheimer’s disease, including a definitions of sporadic as well as familial Alzheimer’s, common signs and symptoms, and diagnosis.

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This video is licensed under a Creative Commons CC-BY-SA 4.0 international license, which means that you’re free to share and adapt it so long as you follow the Attribution and ShareAlike terms and conditions!

Resources:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656563/
http://emedicine.medscape.com/article/1134817-overview#a4
http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-alzheimer-disease?source=search_result&search=alzheimers&selectedTitle=1~150
https://en.wikipedia.org/wiki/Alzheimer%27s_disease

Credits:
Script/audio/visuals: Tanner Marshall, MS
Reviewer: Rishi Desai, MD, MPH

Attributions:
Beta amyloid plaque histology by ‘Jensflorian’ – https://commons.wikimedia.org/wiki/File:Amyloid_plaques_alzheimer_disease_HE_stain.jpg
Neurofibrillary tangles histology by ‘Nephron’ – https://commons.wikimedia.org/wiki/File:Neurofibrillary_tangles_in_the_Hippocampus_of_an_old_person_with_Alzheimer-related_pathology,_HE_4.JPG
Sword slash attack sound effect by Iwan Gabovitch – https://www.freesound.org/people/qubodup/sounds/184422/
Cargo train sound effect by Stephan Schutze – http://soundbible.com/1874-Cargo-Train.html

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